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. 2017 Sep 22;7:12139. doi: 10.1038/s41598-017-11639-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential PAS isoform analysis on FLT1, SDC1 and ADAM12 genes. (a) Superimposed scatter plots showing expression (counts per million mapped reads; CPM) of the four most abundant FLT1 mRNA isoforms. (b) Superimposed scatter plot comparing fractions of total PAS reads mapping to the FLT1 locus represented by each indicated mRNA isoform. For a. and b., each point represents an individual CTRL, EO-PE or LO-PE patient with the color indicating patient type as described in Fig. 1c. A two-way t-test was used for statistical comparisons between indicated groups. Horizontal line: mean; n.s.: not statistically significant. (c) UCSC genome browser view of SDC1 gene illustrating differential PAS isoform abundance (Distal-to-Proximal Switch) for a representative CTRL (top track), EO-PE (middle-track) or LO-PE (bottom track) patient. (d) Same as c, but ADAM12 gene (Proximal-to-Distal Switch).