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. 2017 Sep 22;7:12218. doi: 10.1038/s41598-017-12484-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compatibility of UbasM and current advanced clearing methods for lipophilic fluorescent dye - DiI. (a–d) Confocal fluorescence images of DiI-labeled neural tracts in the hippocampus (in the 1-mm-thick brain slices) with optical clarification by UbasM, CUBIC, uDISCO and ScaleSQ(5) respectively. Significant deformation was noted after CUBIC, uDISCO treatment and obvious deformation after ScaleSQ(5) treatment while no deformation after UbasM treatment. Scale bars: 50 μm. More detailed results were obtained before, after 1 h and 24 h clarification (Supplementary Fig. 4).