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. 2017 Sep 22;7:12192. doi: 10.1038/s41598-017-12305-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Protein interactome network for RCN proteins. Functional interactors of RCN-1 (A), RCN-2 (B), and RCN-3 (C) extracted from STRING tool. This database includes interactions from published literature describing experimentally studied interactions, as well as those from genome analysis using several well-established methods based on domain fusion, phylogenetic profiling and gene neighbourhood concepts. Accordingly, a confidence score for every protein–protein association is assigned to the network. A higher score is assigned when an association is supported by several types of evidence. To minimize false positives as well as false negatives, all interactions tagged as “low-confidence” (<0.150) in STRING database were eliminated from this study. Proteins are represented with nodes and the interactions with continuous lines represent direct interactions. Stronger associations are represented by thicker lines.