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. 2017 Sep 22;7:12192. doi: 10.1038/s41598-017-12305-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of RCN family on ECM components in human cardiac fibroblasts. Dose-response (0.1, 1 and 10 µg/mL) of RCN-1 (A), RCN-2 (B) and RCN-3 (C) on collagen type I, collagen type III, fibronectin, Gal-3 and CT-1 protein levels in human cardiac fibroblasts. Histogram bars represent the mean ± SEM (n > 6 wells at 70% of confluence per condition) of the three independent experiments. Densitometry values were normalized to stain free gel. *p < 0.05; **p < 0.01; ***p < 0.001 vs. Control.