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. 2017 Sep 22;7:12192. doi: 10.1038/s41598-017-12305-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Akt mediates the antifibrotic effect of RCN-3 in human cardiac fibroblasts. Human cardiac fibroblasts were treated with RCN-3 (0.1 µg/mL) for 5, 10, 15, 30 and 60 minutes. Effects of RCN-3 (0.1 µg/mL) on Akt (A), STAT3 (B) and ERK 1/2 (C) at 5, 10, 15, 30 and 60 minutes in human cardiac fibroblasts. Effect of PD98059 (10⁻⁵M) and Wortmannin (10⁻⁵M) on the decrease of collagen type I protein levels induced by RCN-3 (0.1 µg/mL) at 24 hours in human cardiac fibroblast (D). Histogram bars represent the mean ± SEM (n > 6 wells at 70% of confluence per condition) of the three independent experiments. Densitometry values were normalized to stain free gel. *p < 0.05; **p < 0.01; vs. Control. ^†p < 0.05 vs. RCN-3.