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. 2017 Sep 22;8:674. doi: 10.1038/s41467-017-00792-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Natural products containing all-cis-substituted cyclopropanes. a Various natural products containing an all-cis-substituted cyclopropane, all of which have been reported to show intriguing biological activities. b The structures of avenaol and two typical strigolactones. The major differences between these compounds include the AB ring carbon skeleton and the connectivity between the BC rings. The construction of the AB ring of avenaol represents a challenging problem