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. 2017 Sep 22;7:12164. doi: 10.1038/s41598-017-12457-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of functional connections predicted by depression in PD patients. Functional connections predicted by depression while controlling for other neuropsychiatric scales and UPDRS-III are indicated by arrows on a 3D brain template. The significant associations were all positive. The width of the arrows represents the number of functional connections between the regions (see Supplementary Table S2 for the full list of connections). Note, that significant associations were found in the right hemisphere and midline regions. Abbreviations: ACC, anterior cingulate cortex; Hippocampus, hippocampus and parahippocampal gyrus; IFG, inferior frontal gyrus; IPL, inferior parietal lobule; OFC, orbitofrontal cortex; PCC, posterior cingulate cortex; L, left; R, right. P < 0.05, FDR corrected for multiple comparisons.