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. 2017 Sep 22;7:12164. doi: 10.1038/s41598-017-12457-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differences between PD patients and healthy controls in whole-brain functional connectivity. Stronger functional connections in healthy controls are indicated by blue lines and stronger functional connections in PD patients are indicated by red lines (see Supplementary Table S3 for the full list of connections). PD patients showed an extensive reduction in functional connectivity mainly in the sensorimotor, temporal, parietal and subcortical regions. Only the right caudate-right anterior cingulate functional connection was stronger in PD patients (1 out of 122 significant connections). These group-differences were accounted for by either the neuropsychiatric symptoms or the motor deficits of PD patients. Differences between PD patients and healthy controls were evaluated using two sample two-tailed t tests with a statistical threshold of P < 0.05, FDR corrected for multiple comparisons.