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Structures of flavivirus E proteins in the prefusion conformation. In (A), the ribbon diagram of E protein from TBEV, illustrating prominent flexible loops that are poorly immunogenic for CD4+ T cells. In (B), the solvent-accessible area for E proteins from JEV and DFV2, illustrating greater solvent accessibility between monomers of the JEV dimer. JEV, Japanese encephalitis virus.
