Table 1.
Systematic T Cell Epitope Mapping Studies of E Proteins
| Virus | Reference | Subjects | N | Peptides | Detection | Epitope densitya |
|---|---|---|---|---|---|---|
| DFV2 | (45) | Humans | 5 | 100 | Elispot, IFNγ | 1.2 |
| JEV | (55) | Humans | 26 | 62 | Elispot, IFNγ | 3.3 |
| YFV | (56) | C57BL/6 mice | N/A | 50 | Flow, IFNγ | 1 |
| YFV | (30) | BALB/c mice | 3–5 | 81 | Elispot, IFNγ | <6 |
| YFV | (18) | Humans | 40 | 83 | Tetramer flow | 3.6b |
| TBEV | (49) | Humans | 34 | 124 | Elispot, IL-2 | 5c |
| WNV | (4) | C57BL/6 mice | 2–5 | 100 | Flow, IFNγ | <2 |
| WNV | (17) | Humans | 40 | 83 | Tetramer flow | 3.6d |
a
Average number of epitopes in E detected per subject or tetramer allele.
b
Seven alleles tested.
c
Median reported for a subset of subjects.
d
Ten alleles tested.
DFV2, dengue fever virus type 2; JEV, Japanese encephalitis virus; YFV, yellow fever virus; WNV, West Nile virus; TBEV, tick-borne encephalitis virus; IFN, interferon; IL, interleukin; N/A, not available.