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. 2017 Sep 22;16:384. doi: 10.1186/s12936-017-2029-z

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Type I and Type II interferon transcriptional signatures are enriched in the bone marrow during acute malaria. a Pathways enriched with upregulated genes using GSEA. Pathways associated with interferons are highlighted in red. Bars indicate the negative logarithm base 10 of the p value of the enrichment for a given gene set. b Pathways enriched with upregulated genes using MetaCore. Pathways associated with interferons are highlighted in red. c Pathways enriched with downregulated genes using GSEA. d Pathways enriched with downregulated genes using MetaCore. e Clustered heatmap of transcriptional profiles of Type I IFN signature genes. Colours indicate z-score normalized expression values. f Clustered heatmap of transcriptional profiles of Type II IFN signature genes. g ifnγ BM expression levels. h IFNα serum concentrations. i IFNγ serum concentrations