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Binding enhancement of mAbs and their fragments to Env in the presence of sCD4. Binding activity to 293T cells expressing Env of JR-FL was examined using flow cytometry. Histogram of fluorescence intensity shows the binding of negative control (gray), mAb alone (blue) and in the presence of sCD4 (red). Enhancement of binding by CD4 engagement against trimeric Env expressed on the cellular surface was observed for anti-CD4i IgG as well as their fragments
