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. 2017 Sep 22;14:44. doi: 10.1186/s12977-017-0369-y

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Post-binding neutralization activity. The neutralization activities of anti-CD4i mAbs against BaL (a) and JR-FL (b) after attachment of virus and target cell were analyzed. The neutralizing activities of IgGs are shown as open circle, and scFvs are shown as closed square. scFvs targeting the CD4i epitopes inhibited virus infection after virus-attachment to the target cells against both viruses. The statistical significance was calculated using a Student’s t test (*P < 0.05, **P < 0.005, ***P < 0.0005)