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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Figure 22.

Figure 22

Structures of conformationally constrained apoptotic caspases inhibitors. Above – examples where the P2 amide nitrogen was “tied back” to the either or both P3 and P2 side chain. Below – two examples of oxoazepinoindoles (OAIs).