Table 10.
Multiple examples of x-ray crystal structures of caspase-7 adapted from PDB database.
| CASPASE-7 | |||||
|---|---|---|---|---|---|
|
| |||||
| PDB entry | Mutation | Res. | Enzyme info | Ligand | Ref. |
| inhibitors free | |||||
|
| |||||
| 1GQF | C285A | 2.90 | procasp-7 (length 265) | ligand free | 217 |
| 1K86 | C186A | 2.60 | casp-7 (length 253) | ligand free | 218 |
| 1K88 | C186A | 2.70 | procasp-7 (length 253) | ligand free | 218 |
| 3IBF | wild type | 2.50 | casp-7 p20 subunit (length 173) and casp-7 p10 subunit (length 97) | ligand free | 219 |
| 3R5K | R210CC246S | 2.86 | redox controlled version of caspase-7 | ligand free | 220 |
| 4FDL | wild type | 2.80 | casp-7 (length 305) | ligand free | 221 |
| 4HQ0 | D198A | 3.00 | procasp-7 (UNP residues 47-303) | ligand free | 222 |
|
| |||||
| with inhibitors | |||||
| 1I51 | D169A | 2.45 | casp-7 p20 subunit(length 148), casp-7 p11 subunit (length 105) |
second baculoviral IAP repeat of XIAP (XIAP-BIR2, protein inhibitor) |
223 |
| 1KMC | C285A | 2.90 | casp-7 (length 303) |
second baculoviral IAP repeat of XIAP (XIAP-BIR2, protein inhibitor) |
224 |
| 1I4O | wild type | 2.40 | casp-7 (length 280) |
second baculoviral IAP repeat of XIAP( XIAP-BIR2, protein inhibitor) |
225 |
| 1F1J | wild type | 2.35 | casp-7 p20/p10 catalytic domain (length 305) |
Ac-DEVD-CHO (covalent, reversible, peptide inhibitor) |
170 |
| 2QL5 | wild type | 2.34 | casp-7 p20 subunit (length 173), casp-7 p10 subunit (length 97 |
Ac-DMQD- CHO (covalent, reversible, peptide inhibitor) |
173 |
| 2QL7 | wild type | 2.40 | casp-7 p20 subunit (length 173), casp-7 p10 subunit (length 97 |
Ac-IEPD-CHO (covalent, reversible, peptide inhibitor) |
173 |
| 2QL9 | wild type | 2.14 | casp-7 p20 subunit (length 173), casp-7 p10 subunit (length 97 |
Ac-DQMD-CHO (covalent, reversible, peptide inhibitor) |
173 |
| 2QLB | wild type | 2.25 | casp-7 p20 subunit (length 173), casp-7 p10 subunit (length 97 |
Ac-ESMD-CHO (covalent, reversible, peptide inhibitor) |
173 |
| 2QLF | wild type | 2.80 | casp-7 p20 subunit (length 173), casp-7 p10 subunit (length 97 |
Ac-DNLD-CHO (covalent, reversible, peptide inhibitor) |
173 |
| 2QLJ | wild type | 2.60 | casp-7 p20 subunit (length 173), casp-7 p10 subunit (length 97 |
Ac-WEHD-CHO (covalent, reversible, peptide inhibitor) |
173 |
| 3H1P | I213A | 2.61 | caspase-7 (length 260) |
Ac-DEVD-CHO (covalent, reversible, peptide inhibitor) |
226 |
| 3IBC | wild type | 2.75 | casp-7 p20 subunit (length 173) and casp-7 p10 subunit (length 97) |
Ac-YVAD-CHO (covalent, reversible, peptide inhibitor) |
219 |
| 4HQR | D198A | 3.00 | procasp-7 (UNP residues 47-303) |
Ac-DEVD-CHO (covalent, reversible, peptide inhibitor) |
222 |
| 4JR1 | D198A | 2.15 | procasp-7 (UNP residues 57-303) |
Ac-DEVD-CH2Cl (covalent, irreversible, peptide inhibitor) |
227 |
| 4JR2 | D198A | 1.65 | procasp-7/ caspase-7 heterodimer |
Ac-DEVD-CH2Cl (covalent, irreversible, peptide inhibitor) |
227 |
| 4JJ8 | wild type | 2.94 | casp-7 length 255 |
 (irreversible unnatural aa inhibitor; AOMK) |
20 |
| 1SHJ | D169A | 2.80 | casp-7 (length 262) |
 (DICA, allosteric inhibitor) |
228 |
| 1SHL | D192A | 3.00 | casp-7 (length 245) |
 (FICA, allosteric inhibitor) |
228 |
| 4FEA | wild type | 3.79 | casp-7 p20/p10 catalytic domain (UNP residues 57-303) |
 (allosteric inhibitor) |
221 |