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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 12.

Kinetic parameters of potent peptide caspase inhibitors. A high degree of specificity has not been obtained for any caspase. 254

Enzyme Ki, nM k, M−1s−1
Ac-WEHD-CHO 5 Ac-DEVD-CHO 83 Ac-IETD-CHO 89 Cbz-VAD-CH2F 86
Group I Casp-1 0.056 18 <6 280000
Casp-4 97 132 400 5500
Casp-5 43 205 223 130000
Group II Casp-2 > 10000 1710 9400 290
Casp-3 1960 0.23 195 16000
Casp-7 > 10000 1.6 3 280 18000
Group III Casp-6 3090 31 5.6 7100
Casp-8 21.1 0.92 1.05 280000
Casp-9 508 60 108 180000
Casp-10 330 12 27 not determined