Table 12.
Enzyme | Ki, nM | k, M−1s−1 | |||
---|---|---|---|---|---|
| |||||
Ac-WEHD-CHO 5 | Ac-DEVD-CHO 83 | Ac-IETD-CHO 89 | Cbz-VAD-CH2F 86 | ||
Group I | Casp-1 | 0.056 | 18 | <6 | 280000 |
Casp-4 | 97 | 132 | 400 | 5500 | |
Casp-5 | 43 | 205 | 223 | 130000 | |
| |||||
Group II | Casp-2 | > 10000 | 1710 | 9400 | 290 |
Casp-3 | 1960 | 0.23 | 195 | 16000 | |
Casp-7 | > 10000 | 1.6 | 3 280 | 18000 | |
| |||||
Group III | Casp-6 | 3090 | 31 | 5.6 | 7100 |
Casp-8 | 21.1 | 0.92 | 1.05 | 280000 | |
Casp-9 | 508 | 60 | 108 | 180000 | |
Casp-10 | 330 | 12 | 27 | not determined |