. Author manuscript; available in PMC: 2017 Sep 23.

Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 16.

Structures of single amino acid ICE (caspase-1) inhibitors with various leaving groups.

127-135

Reversible mode of inhibition				Irreversible mode of inhibition
R =	K_i, μM	IC₅₀, μM	Ref	R =	k_obs/[I], M⁻¹s⁻¹	Ref
127	119	1034	273	132	11000	264
128	11	73	262	133	5700	248
129	16	55.6	262	134	7100	263
130	0.5	-	269	136	11800	265
131	0.6	-	269