. Author manuscript; available in PMC: 2017 Sep 23.

Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 18.

Examples of irreversible, peptidomimetic caspase-1 inhibitors with diverse P4 position.

Reference 258	k_obs/[I] M⁻¹s⁻¹	Reference 257	k_obs/[I] M⁻¹s⁻¹	Reference 257`	k_obs/[I] M⁻¹s⁻¹
170	268000	174	572000	178	437000
171	148000	175	210000	179	162000
172	90000	176	425000	180	1220000
173	46000	177	340000	181	800000