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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 2.

Table showing kcat/KM (in M−1s−1) values for the most preferred residues in position P4 in a substrate Abz-GXEVD-GVY(NO2)D and position P1′ in substrate Abz-GDEVD-XVY(NO2)D.47

Enzyme P4 kcat/KM P1′ kcat/KM
Caspase-1 Tyrosine 75000 Glycine 2700
Phenylalanine 44500 Serine 1100

Caspase-3 Aspartic acid 200000 Glycine 193000
Serine 200000
Alanine 157000
Tyrosine 63500
Phenylalanine 63000

Caspase-6 Valine 12000 Glycine 1100
Threonine 11000

Caspase-7 Aspartic acid 33000 Glycine 55100
Serine 33000
Alanine 25900
Tyrosine 14500
Phenylalanine 16600

Caspase-8 Leucine 83000 Glycine 38900
Serine 21400
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