. Author manuscript; available in PMC: 2017 Sep 23.

Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 2.

Table showing k_cat/K_M (in M⁻¹s⁻¹) values for the most preferred residues in position P4 in a substrate Abz-GXEVD-GVY(NO₂)D and position P1′ in substrate Abz-GDEVD-XVY(NO₂)D.⁴⁷

Enzyme	P4	k_cat/K_M	P1′	k_cat/K_M
Caspase-1	Tyrosine	75000	Glycine	2700
Caspase-1	Phenylalanine	44500	Serine	1100

Caspase-3	Aspartic acid	200000	Glycine	193000
			Serine	200000
			Alanine	157000
			Tyrosine	63500
			Phenylalanine	63000

Caspase-6	Valine	12000	Glycine	1100
Caspase-6	Threonine	11000

Caspase-7	Aspartic acid	33000	Glycine	55100
			Serine	33000
			Alanine	25900
			Tyrosine	14500
			Phenylalanine	16600

Caspase-8	Leucine	83000	Glycine	38900
Caspase-8			Serine	21400