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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 20.

Some examples of Ac-DEVD-based caspases inhibitors with various P1′ substituents.

graphic file with name nihms905431t116.jpg enzyme assays IC50, nM cellular assays IC50, μM Ref
rh-Casp-1 rh-Casp-3 rh-Casp-7 rh-Casp-8 NT2
- H 83 292 44 716 286 > 100 176
graphic file with name nihms905431t117.jpg
186 		3775 1.3 12 185 n.d.
graphic file with name nihms905431t118.jpg
187 		4575 1.9 14 140 n.d.
graphic file with name nihms905431t119.jpg
188 		1395 46 363 656 n.d.
graphic file with name nihms905431t120.jpg
189 		307 0.8 7.7 16 30
graphic file with name nihms905431t79.jpg
190 		24 0.8 7.2 9.6 n.d.
graphic file with name nihms905431t121.jpg
191 		14 0.1 1.2 1.9 26
graphic file with name nihms905431t122.jpg
192 		451.5 (Ki) 0.261 (Ki) - 159.3 (Ki) - 292