Table 20.
enzyme assays IC50, nM | cellular assays IC50, μM | Ref | ||||
---|---|---|---|---|---|---|
rh-Casp-1 | rh-Casp-3 | rh-Casp-7 | rh-Casp-8 | NT2 | ||
- H 83 | 292 | 44 | 716 | 286 | > 100 | 176 |
186 |
3775 | 1.3 | 12 | 185 | n.d. | |
187 |
4575 | 1.9 | 14 | 140 | n.d. | |
188 |
1395 | 46 | 363 | 656 | n.d. | |
189 |
307 | 0.8 | 7.7 | 16 | 30 | |
190 |
24 | 0.8 | 7.2 | 9.6 | n.d. | |
191 |
14 | 0.1 | 1.2 | 1.9 | 26 | |
192 |
451.5 (Ki) | 0.261 (Ki) | - | 159.3 (Ki) | - | 292 |