Table 30.
enzyme assays IC50, μM Casp-3 |
50% cell protection, nM | ||
---|---|---|---|
PhCH2O- (MX1013) | 274 | 30 | 250 |
CH3- | 306 | 250 | - |
CH3CH2- | 307 | 81 | - |
PhCH2- | 308 | 61 | - |
CH3O- | 309 | 37 | 500 |
PhCH2CH2- | 310 | 98 | - |
Isopropyl-O- | 311 | 35 | - |
CyclopentylCH2O- | 312 | 30 | 300 |
PhCH2CH2O- | 313 | 110 | - |
PhCH2CH2CH2O- | 314 | 46 | - |
2-Cl-PhCH2O- | 315 | 36 | - |
3-Cl-PhCH2O- | 316 | 36 | - |
4-Cl-PhCH2O- | 317 | 34 | - |
2-F-PhCH2O- | 318 | 38 | - |
3-F-PhCH2O- | 319 | 29 | - |
4-F-PhCH2O- | 320 | 28 | 150 |
2,4-di-Cl-PhCH2O- (MX1122) | 275 | 25 | 100 |
3,4-di-Cl-PhCH2O- | 321 | 21 | 150 |
2,5-di-Cl-PhCH2O- | 322 | 15 | 100 |
2,4-di-F-PhCH2O- | 323 | 35 | - |