Table 37.
INHIBITOR | IC50 (μM) | |||||
---|---|---|---|---|---|---|
Casp-3 | Casp-6 | Casp-7 | Casp-8 | Casp-9 | C-3/C-8 ratio | |
Ac-LETD-AOMK 383 | 0.020 | 0.068 | 0.46 | 0.028 | 0.089 | 0.71 |
NH2-βA-L-Q-Hyp-D-AOMK(CV8/9-AOMK) 384 | 43 | 220 | 250 | 0.30 | 0.32 | 143 |
NH2-βA-L-Q-Hyp-D-KE(CV8/9-KE) 385 | 150 | 320 | 400 | 0.30 | 0.64 | 433 |
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kinact/Ki (mM−1s−1) | ||||||
Ac-LETD-AOMK 383 | 490 | n.d. | n.d. | 880 | 1300 | 0.56 |
NH2-βA-L-Q-Hyp-D-AOMK(CV8/9-AOMK) 384 | 0.14 | n.d. | n.d. | 150 | 190 | 0.0009 |
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