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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 47.

IC50 values for ABP with DEVD, DW3 and CV3 as a recognition sequence. 20,63,322

ABP IC50, nM
Casp-3 Casp-6 Casp-7 Casp-8 Casp-9
FAM-DEVD-AOMK 540 18 26 24 29 1100
FAM-CV3-AOMK 541 27 3000 1300 100 3100
Biotin-DEVD-AOMK 542 39 75 38 50 1100
Biotin-CV3-AOMK 543 13 1200 420 53 2500
Rho-Ahx2-DW3-KE 544 25 4000 3500 930 ND
Rho-DEVD-AOMK 545 10 65 17 12 ND
Biotin-CV8/9-KE 546 4500 ND ND 170 ND