Table 6.
CASPASE-2 | |||||
---|---|---|---|---|---|
| |||||
PDB entry | Mutation | Res. | Enzyme info | Ligand | Ref. |
inhibitors free | |||||
3R7S | wild type | 2.25 | p18 subunit (length 160) and p12 subunit (length 112) | ligand free | 39 |
| |||||
with inhibitors | |||||
2P2C | wild type | 3.24 | p18 subunit (167-333) andp12 subunit (348-452) |
AR_F8 (designed ankyrin repeat protein) |
191 |
1PYO | wild type | 1.65 | p18 subunit (151-316) andp12 subunit (331-435) |
Ac-LDESD-CHO (covalent, reversible, peptide inhibitor) |
171 |
3R5J | wild type | 1.77 | p18 subunit (length 160) and p12 subunit (length 112) |
Ac-ADVAD-CHO (covalent, reversible, peptide inhibitor) |
39 |
3R6G | wild type | 2.07 | p18 subunit (length 160) and p12 subunit (length 112) |
Ac-VDVAD-CHO (covalent, reversible, peptide inhibitor) |
39 |
3R7B | wild type | 1.80 | p18 subunit (length 160) and p12 subunit (length 112) |
Ac-DVAD-CHO (covalent, reversible, peptide inhibitor) |
39 |
3R7N | wild type | 2.33 | p18 subunit (length 160) and p12 subunit (length 112) |
Ac-DVAD-CHO two copies (covalent, reversible, peptide inhibitor) |
39 |
3R6L | T380A | 1.90 | p18 subunit (length 160) and p12 subunit (length 112) |
Ac-VDVAD-CHO (covalent, reversible, peptide inhibitor) |
39 |
3RJM | wild type | 2.55 | p18 subunit (167-333) and p12 subunit (348-452) |
(covalent, reversible, peptide aldehyde inhibitor) |
192 |