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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 6.

Multiple examples of x-ray crystal structures of caspase-2 adapted from PDB database.

CASPASE-2
PDB entry Mutation Res. Enzyme info Ligand Ref.
inhibitors free
3R7S wild type 2.25 p18 subunit (length 160) and p12 subunit (length 112) ligand free 39
with inhibitors
2P2C wild type 3.24 p18 subunit (167-333) andp12 subunit (348-452) AR_F8
(designed ankyrin repeat protein)		 191
1PYO wild type 1.65 p18 subunit (151-316) andp12 subunit (331-435) Ac-LDESD-CHO
(covalent, reversible, peptide inhibitor)		 171
3R5J wild type 1.77 p18 subunit (length 160) and p12 subunit (length 112) Ac-ADVAD-CHO
(covalent, reversible, peptide inhibitor)		 39
3R6G wild type 2.07 p18 subunit (length 160) and p12 subunit (length 112) Ac-VDVAD-CHO
(covalent, reversible, peptide inhibitor)		 39
3R7B wild type 1.80 p18 subunit (length 160) and p12 subunit (length 112) Ac-DVAD-CHO
(covalent, reversible, peptide inhibitor)		 39
3R7N wild type 2.33 p18 subunit (length 160) and p12 subunit (length 112) Ac-DVAD-CHO two copies
(covalent, reversible, peptide inhibitor)		 39
3R6L T380A 1.90 p18 subunit (length 160) and p12 subunit (length 112) Ac-VDVAD-CHO
(covalent, reversible, peptide inhibitor)		 39
3RJM wild type 2.55 p18 subunit (167-333) and p12 subunit (348-452) graphic file with name nihms905431t13.jpg
(covalent, reversible, peptide aldehyde inhibitor)		 192