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. Author manuscript; available in PMC: 2017 Sep 23.
Published in final edited form as: Chem Rev. 2015 Nov 9;115(22):12546–12629. doi: 10.1021/acs.chemrev.5b00434

Table 8.

Multiple examples of x-ray crystal structures of caspase-8 adapted from PDB database.

CASPASE-8

PDB entry Mutation Res. Enzyme info Ligand Ref.
inhibitors free
2K7Z C360A NMR monomeric unprocessed catalytic domain (procaspase-8) ligand free 206

with inhibitors
1I4E wild type 3.00 casp-8 p18 subunit and p11 subunit baculoviral p35 protein
(covalent, protein inhibitor)
207
2FUN wild type 3.00 casp-8 p18 subunit and p11 subunit baculoviral p35 protein
(covalent, protein inhibitor)
208
3H11 D359A D369A 1.90 Casp-8 zymogen bound to Ac-IETD-aldehyde inhibitor protease like domain of FLIP 209
1QTN wild type 1.20 casp-8 p18 subunit (length 164) and p11 subunit (length 95) Ac-IETD-CHO
(covalent, reversible, peptide inhibitor)
175
1F9E wild type 2.90 casp-8 p18 subunit (length 153) and p11 subunit (length 89) Z-DEVD-CHO
(covalent, reversible, peptide inhibitor)
210
1QDU wild type 2.80 casp-8 p18 subunit (length 153) and p11 subunit (length 88) Z-EVD-CH2Cl
(covalent, irreversible, peptide inhibitor)
174
3KJQ wild type 1.80 casp-8 p18 subunit (211-374) and casp-8 p10 subunit (385-479) graphic file with name nihms905431t20.jpg
(covalent, irreversible, peptidomimetic inhibitor; AOMK)
211
3KJN wild type 1.80 casp-8 p18 subunit (211-374) and casp-8 p10 subunit (385-479) graphic file with name nihms905431t21.jpg
(covalent, irreversible, peptidomimetic inhibitor; AOMK)
211
4JJ7 wild type 1.18 casp-8 (length 275) graphic file with name nihms905431t22.jpg
(covalent, irreversible inhibitor; AOMK)
20
2C2Z wild type 1.95 casp-8 p18 subunit (218-374) and casp-8 p10 subunit (376-479) graphic file with name nihms905431t23.jpg
(covalent, irreversible, aza-peptide inhibitor)
212
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