Table 8.
Multiple examples of x-ray crystal structures of caspase-8 adapted from PDB database.
| CASPASE-8 | |||||
|---|---|---|---|---|---|
|
| |||||
| PDB entry | Mutation | Res. | Enzyme info | Ligand | Ref. |
| inhibitors free | |||||
| 2K7Z | C360A | NMR | monomeric unprocessed catalytic domain (procaspase-8) | ligand free | 206 |
|
| |||||
| with inhibitors | |||||
| 1I4E | wild type | 3.00 | casp-8 p18 subunit and p11 subunit |
baculoviral p35 protein (covalent, protein inhibitor) |
207 |
| 2FUN | wild type | 3.00 | casp-8 p18 subunit and p11 subunit |
baculoviral p35 protein (covalent, protein inhibitor) |
208 |
| 3H11 | D359A D369A | 1.90 | Casp-8 zymogen bound to Ac-IETD-aldehyde inhibitor | protease like domain of FLIP | 209 |
| 1QTN | wild type | 1.20 | casp-8 p18 subunit (length 164) and p11 subunit (length 95) |
Ac-IETD-CHO (covalent, reversible, peptide inhibitor) |
175 |
| 1F9E | wild type | 2.90 | casp-8 p18 subunit (length 153) and p11 subunit (length 89) |
Z-DEVD-CHO (covalent, reversible, peptide inhibitor) |
210 |
| 1QDU | wild type | 2.80 | casp-8 p18 subunit (length 153) and p11 subunit (length 88) |
Z-EVD-CH2Cl (covalent, irreversible, peptide inhibitor) |
174 |
| 3KJQ | wild type | 1.80 | casp-8 p18 subunit (211-374) and casp-8 p10 subunit (385-479) |
 (covalent, irreversible, peptidomimetic inhibitor; AOMK) |
211 |
| 3KJN | wild type | 1.80 | casp-8 p18 subunit (211-374) and casp-8 p10 subunit (385-479) |
 (covalent, irreversible, peptidomimetic inhibitor; AOMK) |
211 |
| 4JJ7 | wild type | 1.18 | casp-8 (length 275) |
 (covalent, irreversible inhibitor; AOMK) |
20 |
| 2C2Z | wild type | 1.95 | casp-8 p18 subunit (218-374) and casp-8 p10 subunit (376-479) |
 (covalent, irreversible, aza-peptide inhibitor) |
212 |