Table 9.
Multiple examples of x-ray crystal structures of caspase-9 adapted from PDB database.
| CASPASE-9 | |||||
|---|---|---|---|---|---|
|
| |||||
| PDB entry | Mutation | Res. | Enzyme info | Ligand | Ref. |
| inhibitors free | |||||
|
| |||||
| 3YGS | wild type | 2.50 | APAF1 (CARD, length 95) and procaspase 9 (prodomain, length 97) | ligand free | 213 |
| 2AR9 | C287S, G402C, C403I, F404V, N405S, F406M | 2.80 | dimeric casp-9 catalytic domain (residues 140-416) | D-malate | 214 |
|
| |||||
| with inhibitors | |||||
| 1NW9 | wild type | 2.40 | casp-9 catalytic domain (residues 139-416) |
third baculoviral IAP repeat of XIAP (XIAP-BIR3, protein inhibitor) |
215 |
| 1JXQ | wild type | 2.80 | delta CARD caspase-9 |
Z-VAD-CH2F (covalent, irreversible, peptide inhibitor) |
216 |