Table 2.
Univariate and multivariate Cox proportional hazard models for overall survival (OS)
| Overall survival (OS) | ||||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| Age | ||||
| < 65 y | 1 | |||
| ≥ 65 y | 1.65 (0.93–2.27) | 0.126 | ||
| Gender | ||||
| Male | 1 | |||
| Female | 1.27 (0.83–2.01) | 0.149 | ||
| Location | ||||
| Left | 1 | |||
| Others | 0.82 (0.56–1.41) | 0.632 | ||
| T stage | ||||
| T1 + T2 | 1 | |||
| T3 + T4 | 1.72 (0.52–5.29) | 0.391 | ||
| N stage | ||||
| N0 | 1 | 1 | ||
| N1 + N2 | 6.71 (3.91–11.68) | <0.001* | 0.35 (0.04–1.92) | 0.163 |
| AJCC stage | ||||
| II | 1 | 1 | ||
| III | 5.47 (4.25–10.27) | <0.001* | 18.38 (2.93–152.17) | 0.008* |
| Histologic grade | ||||
| Well Differentiated | 1 | 1 | ||
| Poorly differentiated | 3.42 (1.98–5.24) | <0.001* | 2.34 (1.36–3.57) | 0.316 |
| Venous & Lymphatic invasion | ||||
| No | 1 | |||
| Yes | 0.75 (0.37–0.95) 0.271 | |||
| Peritoneal Dissemination | ||||
| Absent | 1 | |||
| Present | 0.52 (0.24–0.82) | 0.493 | ||
| Liver Metastsis | ||||
| Negative | 1 | 1 | ||
| Positive Multinodular | 0.48 (0.29–0.81) | 0.001* | 0.59 (0.36–0.98) 0.024* | |
| MiR-19b-3p | ||||
| Low | 1 | 1 | ||
| High | 2.79 (1.80–4.67) | <0.001* | 2.23 (1.42–3.58) | 0.008* |
HR: Hazard ratio; CI: Confidence interval
*P < 0.05 was considered significant