Table 3.
Univariate and multivariate Cox proportional hazard models for disease free survival (DFS)
| Disease free survival (DFS) | ||||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| Age | ||||
| < 65 y | 1 | |||
| ≥ 65 y | 1.76 (0.97–2.68) | 0.079 | ||
| Gender | ||||
| Male | 1 | |||
| Female | 1.53 (0.93–2.31) | 0.372 | ||
| Location | ||||
| Left | 1 | |||
| Others | 0.74 (0.52–1.39) | 0.354 | ||
| T stage | ||||
| T1 + T2 | 1 | |||
| T3 + T4 | 1.85 (0.56–5.37) | 0.482 | ||
| N stage | ||||
| N0 | 1 | 1 | ||
| N1 + N2 | 5.26 (2.42–10.46) | <0.001* | 4.21 (2.50–7.94) | <0.001* |
| AJCC stage | ||||
| II | 1 | 1 | ||
| III | 6.82 (3.72–10.93) | <0.001* | 2.29 (1.21–3.82) | 0.381 |
| Histologic grade | ||||
| Well Differentiated | 1 | 1 | ||
| Poorly differentiated | 2.83 (1.79–4.29) | <0.001* | 2.20 (1.35–3.62) | 0.282 |
| Venous & Lymphatic invasion | ||||
| No | 1 | |||
| Yes | 0.72 (0.56–1.27) | 0.413 | ||
| Peritoneal Dissemination | ||||
| Absent | 1 | |||
| Present | 0.84 (0.68–1.53) | 0.281 | ||
| Liver Metastsis | ||||
| Negative | 1 | 1 | ||
| Positive Multinodular | 0.52 (0.29–0.83) | 0.003* | 0.69 (0.36–1.23) | 0.032* |
| MiR-19b-3p | ||||
| Low | 1 | 1 | ||
| High | 3.34 (1.97–5.23) | <0.001* | 2.73 (1.76–3.89) | 0.016* |
HR: Hazard ratio; CI: Confidence interval
*P < 0.05 was considered significant