FIG 7.

Drug accumulation comparison between multiple doses of micafungin (5 mg/kg) and a single dose of CD101 (20 mg/kg). Absolute drug level was measured for lesions and surrounding uninvolved tissues from liver samples collected at 48 h and 72 h after the first dose of micafungin and those treated with a single dose of CD101 and collected at the matched time points. Error bars indicate means ± SD from 3 to 5 liver pieces or distinct lesions. ***, P < 0.001. Drug levels of CD101 were significantly higher than those of micafungin in corresponding sites (lesion or uninvolved tissue) at specified time points.