TABLE 4.
Genetic analysis of macrolide-resistant M. abscessus clinical isolates
| Mutation or sequevar | No. (%) of patients with mutationa |
|---|---|
| Presence of point mutation in rrlb | 13 (100) |
| Adenine → guanine | 7 (54) |
| A2058G | 4 |
| A2059G | 3 |
| Adenine → cytosine | 5 (38) |
| A2058C | 5 |
| A2059C | 0 |
| Adenine → thymine | 1 (8) |
| A2058T | 1 |
| A2059T | 0 |
| 28th sequevar of erm(41)c | |
| T28 | 11 (85) |
| C28 | 2 (15) |
a
The total number of patients in the study was 13.
b
Nucleotides 2058 and 2059 (Escherichia coli numbering) of rrl, for which the wild-type sequence is AA. A, adenine; G, guanine; C, cytosine; T, thymine.
c
Numbering system of erm(41), with the GTG start codon as 1.