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Disruption of biofilms in vitro. Bacterial biofilm was formed on conical plastic pegs in a 96-well format. Pegs were treated with IgG isotype control MAb (left) or TRL1068 (right) at 1.2 μg/ml for 12 h. Adherent A. baumannii bacterial cells were visualized by SEM at ×5,000 and ×10,000 magnifications. TRL1068-treated pegs have a thinner biofilm and bacterial cells are less densely packed than on the control pegs.
