FIG 3.

In vivo efficacy of TRL1068 with or without imipenem (IPM) in a murine catheter-related skin and soft tissue infection model due to a multidrug-resistant A. baumannii strain. Median and quartile values are shown, with outliers being denoted by circles. TRL1068 potentiates imipenem activity against A. baumannii (10⁶ CFU). (A) Imipenem at 100 mg/kg BID; (B) imipenem at 150 mg/kg QID. For data in both panels, TRL1068 was given at 15 mg/kg on days 1 and 4; the control includes an isotype control nonimmune MAb.