TABLE 3.
Mutations in the fluoroquinolone resistance-determining region (QRDR) of gyrA and fluoroquinolone MICs
| Mutation | FQ | No. of isolates with MIC (mg/liter) of: |
No. (%) of resistant isolates | No. (%) of high-level-resistant isolatesa | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.13 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | Total | ||||
| Gly88Ala | MFX | 1 | 1 | 0 (0.0) | 0 (0.0) | |||||||
| GAT | 1 | 1 | 0 (0.0) | 0 (0.0) | ||||||||
| Ala90Val | MFX | 1 | 2 | 6 | 10 | 3 | 22 | 19 (86.4) | 3 (13.6) | |||
| GAT | 1 | 1 | 3 | 8 | 8 | 1 | 22 | 17 (77.3) | 1 (4.5) | |||
| Ser91Pro | MFX | 2 | 2 | 1 | 1 | 6 | 6 (100.0) | 2 (33.3) | ||||
| GAT | 2 | 2 | 1 | 1 | 6 | 6 (100.0) | 2 (33.3) | |||||
| Asp94Gly | MFX | 1 | 9 | 21 | 8 | 2 | 41 | 41 (100.0) | 31 (75.6) | |||
| GAT | 1 | 5 | 17 | 15 | 3 | 41 | 40 (97.6) | 18 (43.9) | ||||
| Asp94Asn | MFX | 1 | 3 | 4 | 4 (100.0) | 3 (75.0) | ||||||
| GAT | 1 | 3 | 4 | 4 (100.0) | 0 (0.0) | |||||||
| Asp94Ala | MFX | 1 | 1 | 1 | 3 | 3 (100.0) | 1 (33.3) | |||||
| GAT | 1 | 1 | 1 | 3 | 2 (66.7) | 1 (33.3) | ||||||
| Asp94Tyr | MFX | 2 | 1 | 3 | 3 (100.0) | 1 (33.3) | ||||||
| GAT | 3 | 3 | 3 (100.0) | 0 (0.0) | ||||||||
| Asp94His | MFX | 1 | 1 | 1 (100.0) | 0 (0.0) | |||||||
| GAT | 1 | 1 | 1 (100.0) | 0 (0.0) | ||||||||
| No mutation | MFX | 1 | 3 | 3 | 1 | 1 | 9 | 5 (55.6) | 1 (11.1) | |||
| GAT | 1 | 5 | 2 | 1 | 9 | 3 (33.3) | 1 (11.1) | |||||
a
High-level resistant was defined as a MIC value higher than 2 mg/liter.