TABLE 2.

CLSI-ECVs for S. schenckii sensu stricto and S. brasiliensis based on MICs from 3 to 9 laboratories determined by the CLSI broth microdilution method

Species	Antifungal agent	No. of isolates tested	MIC (μg/ml)		ECVb
			Range	Modea	≥95%	≥97.5%
S. schenckii	Amphotericin B	263	0.03 to 32	1	4	4
	Itraconazole	194	0.06 to ≥32	0.5	2	2
	Ketoconazole	NDc
	Posaconazole	301	0.06 to 16	1	2	4
	Voriconazole	252	0.5 to >32	16	64	64
	Terbinafine	ND
S. brasiliensis	Amphotericin B	486	0.03 to 8	1	4	4
	Itraconazole	306	0.01 to 32	1	2	2
	Ketoconazole	338	0.01 to 2	0.5	2	2
	Posaconazole	200	0.01 to 4	1	2	2
	Voriconazole	200	0.5 to 32	8	32	32
	Terbinafine	368	≤0.01 to 1	0.06	0.12	0.25

^aMode, most frequent MIC.

^bCalculated CLSI ECVs comprising ≥95% and ≥97.5% of the statistically modeled population; the values are based on MICs determined by the CLSI M38-A2 broth dilution method (21).

^cND, not determined, due to an insufficient number of isolates or laboratories for ECV calculation.