TABLE 1.

Activity of antifungal agents tested using the CLSI reference broth microdilution method against fungal organism groups according to clinical breakpoints and/or ECV interpretative criteria^a

Organism (no. of isolates tested) and antifungal agent	MIC50 or MEC50 (μg/ml)	MIC90 or MEC90 (μg/ml)	% of isolates
			CLSI method		ECV
			S	R	WT	NWT
C. albicans (1,310)
Anidulafungin	0.015	0.03	99.9	0.0	99.8	0.2
Caspofungin	0.015	0.03	99.8	0.2
Micafungin	0.015	0.03	99.8	0.2	99.8	0.2
Fluconazole	≤0.12	0.25	99.6	0.4
Voriconazole	≤0.008	0.015	99.9	<0.1
Posaconazole	0.03	0.06
Amphotericin B	1	1			100.0	0.0
C. glabrata (514)
Anidulafungin	0.06	0.12	95.9	2.5	97.5	2.5
Caspofungin	0.03	0.06	96.9	2.5
Micafungin	0.015	0.03	97.5	2.3	96.9	3.1
Fluconazole	4	16	92.0b	8.0
Voriconazole	0.12	0.5
Posaconazole	0.5	1
Amphotericin B	1	1			100.0	0.0
C. parapsilosis (417)
Anidulafungin	2	4	88.7	0.0	100.0	0.0
Caspofungin	0.25	0.5	100.0	0.0
Micafungin	1	2	100.0	0.0	100.0	0.0
Fluconazole	0.5	2	95.7	3.8
Voriconazole	0.015	0.03	96.4	0.7
Posaconazole	0.06	0.12
Amphotericin B	1	1			100.0	0.0
C. tropicalis (264)
Anidulafungin	0.015	0.03	100.0	0.0	100.0	0.0
Caspofungin	0.015	0.06	100.0	0.0
Micafungin	0.015	0.06	100.0	0.0	99.6	0.4
Fluconazole	0.25	0.5	96.2	2.7	96.2	3.8
Voriconazole	0.015	0.06	97.0	2.3
Posaconazole	0.03	0.12
Amphotericin B	1	1			100.0	0.0
C. krusei (93)
Anidulafungin	0.06	0.12	100.0	0.0	100.0	0.0
Caspofungin	0.12	0.25	100.0	0.0
Micafungin	0.06	0.12	100.0	0.0	100.0	0.0
Fluconazole	32	64
Voriconazole	0.25	0.5	100.0	0.0
Posaconazole	0.25	0.5
Amphotericin B	1	2			100.0	0.0
C. dubliniensis (58)
Anidulafungin	0.03	0.12			100.0	0.0
Caspofungin	0.03	0.06
Micafungin	0.03	0.06			100.0	0.0
Fluconazole	≤0.12	0.25
Voriconazole	≤0.008	0.015
Posaconazole	0.03	0.06
Amphotericin B	0.5	1
C. lusitaniae (39)
Anidulafungin	0.25	0.5			100.0	0.0
Caspofungin	0.12	0.25
Micafungin	0.12	0.25			100.0	0.0
Fluconazole	0.5	1
Voriconazole	≤0.008	≤0.008
Posaconazole	0.06	0.12
Amphotericin B	0.5	1
C. guilliermondii (14)
Anidulafungin	2	4	92.9	0.0	100.0	0.0
Caspofungin	0.5	1	100.0	0.0
Micafungin	1	1	100.0	0.0	100.0	0.0
Fluconazole	2	64
Voriconazole	0.06	1
Posaconazole	0.5	>8
Amphotericin B	0.25	1
A. fumigatus (391)
Anidulafungin	≤0.008	0.03
Caspofungin	0.015	0.03			100.0	0.0
Micafungin	≤0.008	0.015
Itraconazole	0.5	1			99.5	0.5
Voriconazole	0.5	0.5			99.7	0.3
Posaconazole	0.25	0.5
Amphotericin B	1	2			100.0	0.0
A. niger (15)
Anidulafungin	≤0.008	0.03
Caspofungin	0.015	0.03			100.0	0.0
Micafungin	≤0.008	0.015
Itraconazole	0.5	1			100.0	0.0
Voriconazole	0.5	0.5			100.0	0.0
Posaconazole	0.25	0.5			100.0	0.0
Amphotericin B	1	2			100.0	0.0
A. terreus (12)
Anidulafungin	≤0.008	0.03
Caspofungin	0.015	0.03			100.0	0.0
Micafungin	≤0.008	0.015
Itraconazole	0.5	1			100.0	0.0
Voriconazole	0.5	0.5			100.0	0.0
Posaconazole	0.25	0.5			100.0	0.0
Amphotericin B	1	2			100.0	0.0

^aMEC₅₀ and MEC₉₀, minimum effective concentrations for 50% and 90% of isolates, respectively; CLSI, Clinical and Laboratory Standards Institute; S, susceptible; R, resistant; ECV, epidemiologic cutoff value; WT, wild-type; NWT, non-wild-type.

^bSusceptible dose dependent.