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. 2017 Sep 22;61(10):e00906-17. doi: 10.1128/AAC.00906-17

TABLE 2.

Activity of antifungal agents tested against uncommon yeast species with ≥3 isolates

Organism/organism group (no. of isolates) No. of isolates (cumulative %) at the following MIC (μg/ml):
 MIC50 (μg/ml) MIC90 (μg/ml)
≤0.008 0.015 0.03 0.06 0.12 0.25 0.5 1 2 4 8 16 32 64 128 >a
Candida haemulonii (4)
    Anidulafungin 0 (0.0) 2 (50.0) 1 (75.0) 1 (100.0) 0.12
    Caspofungin 0 (0.0) 1 (25.0) 1 (50.0) 2 (100.0) 0.06
    Micafungin 0 (0.0) 4 (100.0) 0.12
    Fluconazole 0 (0.0) 1 (25.0) 1 (50.0) 2 (100.0) 1
    Voriconazole 0 (0.0) 2 (50.0) 2 (100.0) 0.015
    Posaconazole 0 (0.0) 2 (50.0) 2 (100.0) 0.06
    Amphotericin B 0 (0.0) 1 (25.0) 3 (100.0) 2
Candida metapsilosis (8)
    Anidulafungin 0 (0.0) 4 (50.0) 2 (75.0) 1 (87.5) 1 (100.0) 0.25
    Caspofungin 0 (0.0) 1 (12.5) 5 (75.0) 1 (87.5) 1 (100.0) 0.12
    Micafungin 0 (0.0) 1 (12.5) 3 (50.0) 3 (87.5) 1 (100.0) 0.25
    Fluconazole 0 (0.0) 1 (12.5) 6 (87.5) 1 (100.0) 1
    Voriconazole 0 (0.0) 3 (37.5) 4 (87.5) 0 (87.5) 1 (100.0) 0.03
    Posaconazole 0 (0.0) 2 (25.0) 5 (87.5) 0 (87.5) 1 (100.0) 0.06
    Amphotericin B 0 (0.0) 2 (25.0) 6 (100.0) 1
Candida fabianii (3)
    Anidulafungin 0 (0.0) 3 (100.0) 0.015
    Caspofungin 0 (0.0) 3 (100.0) 0.015
    Micafungin 0 (0.0) 2 (66.7) 1 (100.0) 0.015
    Fluconazole 0 (0.0) 1 (33.3) 2 (100.0) 4
    Voriconazole 0 (0.0) 1 (33.3) 1 (66.7) 1 (100.0) 0.06
    Posaconazole 0 (0.0) 1 (33.3) 2 (100.0) 0.5
    Amphotericin B 0 (0.0) 3 (100.0) 1
Candida inconspicua (6)
    Anidulafungin 2 (33.3) 2 (66.7) 2 (100.0) 0.015
    Caspofungin 0 (0.0) 2 (33.3) 2 (66.7) 1 (83.3) 1 (100.0) 0.03
    Micafungin 2 (33.3) 0 (33.3) 2 (66.7) 1 (83.3) 1 (100.0) 0.03
    Fluconazole 0 (0.0) 5 (83.3) 1 (100.0) 16
    Voriconazole 0 (0.0) 2 (33.3) 4 (100.0) 0.25
    Posaconazole 0 (0.0) 5 (83.3) 1 (100.0) 0.25
    Amphotericin B 0 (0.0) 1 (16.7) 2 (50.0) 3 (100.0) 0.5
Candida kefyr (22)
    Anidulafungin 0 (0.0) 7 (31.8) 7 (63.6) 8 (100.0) 0.06 0.12
    Caspofungin 11 (50.0) 10 (95.5) 1 (100.0) ≤0.008 0.015
    Micafungin 0 (0.0) 1 (4.5) 11 (54.5) 9 (95.5) 1 (100.0) 0.03 0.06
    Fluconazole 6 (27.3) 7 (59.1) 8 (95.5) 1 (100.0) 0.25 0.5
    Voriconazole 15 (68.2) 7 (100.0) ≤0.008 0.015
    Posaconazole 0 (0.0) 4 (18.2) 3 (31.8) 6 (59.1) 5 (81.8) 4 (100.0) 0.06 0.25
    Amphotericin B 0 (0.0) 3 (13.6) 18 (95.5) 1 (100.0) 1 1
Candida lipolytica (5)
    Anidulafungin 0 (0.0) 4 (80.0) 1 (100.0) 0.25
    Caspofungin 0 (0.0) 2 (40.0) 3 (100.0) 0.25
    Micafungin 0 (0.0) 1 (20.0) 3 (80.0) 1 (100.0) 0.5
    Fluconazole 0 (0.0) 1 (20.0) 2 (60.0) 0 (60.0) 0 (60.0) 0 (60.0) 2 (100.0) 2
    Voriconazole 0 (0.0) 2 (40.0) 1 (60.0) 0 (60.0) 0 (60.0) 0 (60.0) 0 (60.0) 2 (100.0) 0.03
    Posaconazole 0 (0.0) 3 (60.0) 0 (60.0) 1 (80.0) 1 (100.0) 0.25
    Amphotericin B 0 (0.0) 1 (20.0) 4 (100.0) 1
Candida orthopsilosis (34)
    Anidulafungin 0 (0.0) 5 (14.7) 9 (41.2) 15 (85.3) 5 (100.0) 1 2
    Caspofungin 0 (0.0) 5 (14.7) 15 (58.8) 11 (91.2) 3 (100.0) 0.12 0.25
    Micafungin 0 (0.0) 3 (8.8) 10 (38.2) 17 (88.2) 4 (100.0) 0.5 1
    Fluconazole 1 (2.9) 3 (11.8) 13 (50.0) 9 (76.5) 4 (88.2) 1 (91.2) 0 (91.2) 1 (94.1) 1 (97.1) 0 (97.1) 1 (100.0) 0.5 4
    Voriconazole 6 (17.6) 10 (47.1) 9 (73.5) 4 (85.3) 2 (91.2) 0 (91.2) 2 (97.1) 1 (100.0) 0.03 0.12
    Posaconazole 0 (0.0) 8 (23.5) 8 (47.1) 15 (91.2) 2 (97.1) 1 (100.0) 0.12 0.12
    Amphotericin B 0 (0.0) 19 (55.9) 15 (100.0) 0.5 1
Candida pelliculosa (5)
    Anidulafungin 4 (80.0) 1 (100.0) ≤0.008
    Caspofungin 3 (60.0) 0 (60.0) 2 (100.0) ≤0.008
    Micafungin 2 (40.0) 2 (80.0) 1 (100.0) 0.015
    Fluconazole 0 (0.0) 3 (60.0) 1 (80.0) 1 (100.0) 2
    Voriconazole 0 (0.0) 2 (40.0) 2 (80.0) 1 (100.0) 0.12
    Posaconazole 0 (0.0) 1 (20.0) 1 (40.0) 2 (80.0) 1 (100.0) 0.5
    Amphotericin B 0 (0.0) 1 (20.0) 4 (100.0) 0.5
Cryptococcus neoformans (3)
    Anidulafungin 0 (0.0) 3 (100.0) >8
    Caspofungin 0 (0.0) 3 (100.0) >8
    Micafungin 0 (0.0) 3 (100.0) >8
    Fluconazole 0 (0.0) 1 (33.3) 2 (100.0) 4
    Voriconazole 0 (0.0) 1 (33.3) 2 (100.0) 0.06
    Posaconazole 0 (0.0) 3 (100.0) 0.25
    Amphotericin B 0 (0.0) 3 (100.0) 0.5
Cryptococcus neoformans var. grubii (78)
    Anidulafungin 0 (0.0) 1 (1.3) 0 (1.3) 5 (7.7) 72 (100.0) >8 >8
    Caspofungin 0 (0.0) 1 (1.3) 8 (11.5) 69 (100.0) >8 >8
    Micafungin 0 (0.0) 1 (1.3) 0 (1.3) 2 (3.8) 75 (100.0) >8 >8
    Fluconazole 0 (0.0) 1 (1.3) 7 (10.3) 34 (53.8) 35 (98.7) 1 (100.0) 2 4
    Voriconazole 0 (0.0) 4 (5.1) 37 (52.6) 36 (98.7) 1 (100.0) 0.03 0.06
    Posaconazole 0 (0.0) 3 (3.8) 13 (20.5) 32 (61.5) 30 (100.0) 0.12 0.25
    Amphotericin B 0 (0.0) 1 (1.3) 46 (60.3) 31 (100.0) 0.5 1
Cryptococcus neoformans var. neoformans (8)
    Anidulafungin 0 (0.0) 1 (12.5) 0 (12.5) 2 (37.5) 5 (100.0) >8
    Caspofungin 0 (0.0) 6 (75.0) 2 (100.0) 8
    Micafungin 0 (0.0) 1 (12.5) 0 (12.5) 0 (12.5) 2 (37.5) 5 (100.0) >8
    Fluconazole 0 (0.0) 1 (12.5) 4 (62.5) 2 (87.5) 1 (100.0) 1
    Voriconazole 0 (0.0) 2 (25.0) 5 (87.5) 1 (100.0) 0.03
    Posaconazole 0 (0.0) 3 (37.5) 4 (87.5) 1 (100.0) 0.12
    Amphotericin B 0 (0.0) 1 (12.5) 7 (100.0) 0.5
Geotrichum clavatum (5)
    Anidulafungin 0 (0.0) 1 (20.0) 4 (100.0) 4
    Caspofungin 0 (0.0) 2 (40.0) 1 (60.0) 2 (100.0) 8
    Micafungin 0 (0.0) 1 (20.0) 0 (20.0) 3 (80.0) 1 (100.0) 2
    Fluconazole 0 (0.0) 1 (20.0) 3 (80.0) 1 (100.0) 8
    Voriconazole 0 (0.0) 4 (80.0) 0 (80.0) 1 (100.0) 0.12
    Posaconazole 0 (0.0) 2 (40.0) 3 (100.0) 0.5
    Amphotericin B 0 (0.0) 2 (40.0) 3 (100.0) 1
Magnusiomyces capitatus (7)
    Anidulafungin 0 (0.0) 1 (14.3) 6 (100.0) 4
    Caspofungin 0 (0.0) 1 (14.3) 2 (42.9) 4 (100.0) >8
    Micafungin 0 (0.0) 1 (14.3) 0 (14.3) 0 (14.3) 2 (42.9) 4 (100.0) >8
    Fluconazole 0 (0.0) 1 (14.3) 0 (14.3) 0 (14.3) 1 (28.6) 5 (100.0) 8
    Voriconazole 0 (0.0) 1 (14.3) 0 (14.3) 1 (28.6) 4 (85.7) 1 (100.0) 0.25
    Posaconazole 0 (0.0) 1 (14.3) 0 (14.3) 1 (28.6) 2 (57.1) 3 (100.0) 0.25
    Amphotericin B 0 (0.0) 7 (100.0) 1
Rhodotorula mucilaginosa (6)
    Anidulafungin 0 (0.0) 6 (100.0) >8
    Caspofungin 0 (0.0) 2 (33.3) 4 (100.0) >8
    Micafungin 0 (0.0) 6 (100.0) >8
    Fluconazole 0 (0.0) 1 (16.7) 5 (100.0) >128
    Voriconazole 0 (0.0) 1 (16.7) 0 (16.7) 3 (66.7) 2 (100.0) 4
    Posaconazole 0 (0.0) 3 (50.0) 2 (83.3) 0 (83.3) 0 (83.3) 1 (100.0) 1
    Amphotericin B 0 (0.0) 2 (33.3) 4 (100.0) 1
Saccharomyces cerevisiae (19)
    Anidulafungin 0 (0.0) 4 (21.1) 6 (52.6) 7 (89.5) 2 (100.0) 0.12 0.5
    Caspofungin 0 (0.0) 2 (10.5) 5 (36.8) 6 (68.4) 5 (94.7) 1 (100.0) 0.12 0.25
    Micafungin 0 (0.0) 3 (15.8) 11 (73.7) 3 (89.5) 2 (100.0) 0.12 0.5
    Fluconazole 0 (0.0) 2 (10.5) 4 (31.6) 4 (52.6) 6 (84.2) 3 (100.0) 2 8
    Voriconazole 0 (0.0) 1 (5.3) 7 (42.1) 5 (68.4) 5 (94.7) 1 (100.0) 0.06 0.12
    Posaconazole 0 (0.0) 3 (15.8) 8 (57.9) 5 (84.2) 3 (100.0) 0.25 1
    Amphotericin B 0 (0.0) 5 (26.3) 14 (100.0) 1 1
Trichosporon asahii (14)
    Anidulafungin 0 (0.0) 2 (14.3) 12 (100.0) >8 >8
    Caspofungin 0 (0.0) 2 (14.3) 12 (100.0) >8 >8
    Micafungin 0 (0.0) 14 (100.0) >8 >8
    Fluconazole 0 (0.0) 1 (7.1) 0 (7.1) 8 (64.3) 1 (71.4) 3 (92.9) 0 (92.9) 1 (100.0) 4 16
    Voriconazole 0 (0.0) 1 (7.1) 5 (42.9) 3 (64.3) 4 (92.9) 0 (92.9) 1 (100.0) 0.12 0.25
    Posaconazole 0 (0.0) 1 (7.1) 7 (57.1) 4 (85.7) 2 (100.0) 0.25 1
    Amphotericin B 0 (0.0) 1 (7.1) 13 (100.0) 1 1
Trichosporon mycotoxinivorans (3)
    Anidulafungin 0 (0.0) 3 (100.0) >8
    Caspofungin 0 (0.0) 1 (33.3) 2 (100.0) >8
    Micafungin 0 (0.0) 1 (33.3) 0 (33.3) 2 (100.0) >8
    Fluconazole 0 (0.0) 1 (33.3) 2 (100.0) 4
    Voriconazole 0 (0.0) 3 (100.0) 0.12
    Posaconazole 0 (0.0) 2 (66.7) 1 (100.0) 0.25
    Amphotericin B 0 (0.0) 3 (100.0) 1
a

> represents the dilution greater than the highest dilution tested.