. 2017 Sep 22;61(10):e00906-17. doi: 10.1128/AAC.00906-17

TABLE 3.

Activity of antifungal agents tested against uncommon mold species with ≥3 isolates

Organism/organism group (no. of isolates)	No. of isolates (cumulative %) at the following MIC/MEC (μg/ml):												MIC₅₀ (μg/ml)	MIC₉₀ (μg/ml)
Organism/organism group (no. of isolates)	≤0.008	0.015	0.03	0.06	0.12	0.25	0.5	1	2	4	8	>^a	MIC₅₀ (μg/ml)	MIC₉₀ (μg/ml)
Aspergillus nidulans SC (9)
Anidulafungin	0 (0.0)	5 (55.6)	2 (77.8)	1 (88.9)	1 (100.0)								0.015
Caspofungin	3 (33.3)	1 (44.4)	1 (55.6)	0 (55.6)	2 (77.8)	0 (77.8)	0 (77.8)	0 (77.8)	2 (100.0)				0.03
Micafungin	3 (33.3)	2 (55.6)	2 (77.8)	2 (100.0)									0.015
Itraconazole				0 (0.0)	1 (11.1)	1 (22.2)	7 (100.0)						0.5
Voriconazole			0 (0.0)	1 (11.1)	6 (77.8)	2 (100.0)							0.12
Posaconazole				0 (0.0)	1 (11.1)	5 (66.7)	3 (100.0)						0.25
Amphotericin B							0 (0.0)	4 (44.4)	5 (100.0)				2
Aspergillus nidulans (8)
Anidulafungin	0 (0.0)	5 (62.5)	2 (87.5)	0 (87.5)	1 (100.0)								0.015
Caspofungin	3 (37.5)	1 (50.0)	1 (62.5)	0 (62.5)	1 (75.0)	0 (75.0)	0 (75.0)	0 (75.0)	2 (100.0)				0.015
Micafungin	3 (37.5)	1 (50.0)	2 (75.0)	2 (100.0)									0.015
Itraconazole					0 (0.0)	1 (12.5)	7 (100.0)						0.5
Voriconazole				0 (0.0)	6 (75.0)	2 (100.0)							0.12
Posaconazole					0 (0.0)	5 (62.5)	3 (100.0)						0.25
Amphotericin B							0 (0.0)	3 (37.5)	5 (100.0)				2
Aspergillus versicolor (4)
Anidulafungin	0 (0.0)	2 (50.0)	1 (75.0)	1 (100.0)									0.015
Caspofungin	0 (0.0)	2 (50.0)	1 (75.0)	1 (100.0)									0.015
Micafungin		0 (0.0)	3 (75.0)	1 (100.0)									0.03
Itraconazole						0 (0.0)	3 (75.0)	0 (75.0)	1 (100.0)				0.5
Voriconazole					0 (0.0)	2 (50.0)	1 (75.0)	0 (75.0)	1 (100.0)				0.25
Posaconazole						0 (0.0)	3 (75.0)	1 (100.0)					0.5
Amphotericin B								0 (0.0)	4 (100.0)				2

Fusarium solani SC (15)
Anidulafungin											0 (0.0)	15 (100.0)	>8	>8
Caspofungin											0 (0.0)	15 (100.0)	>8	>8
Micafungin											0 (0.0)	15 (100.0)	>8	>8
Itraconazole											0 (0.0)	15 (100.0)	>8	>8
Voriconazole									0 (0.0)	4 (26.7)	10 (93.3)	1 (100.0)	8	8
Posaconazole											0 (0.0)	15 (100.0)	>8	>8
Amphotericin B							0 (0.0)	4 (26.7)	10 (93.3)			1 (100.0)	2	2
Scedosporium apiospermum/Scedosporium boydii (11)
Anidulafungin			0 (0.0)	1 (9.1)	0 (9.1)	0 (9.1)	0 (9.1)	0 (9.1)	1 (18.2)	9 (100.0)			4	4
Caspofungin		0 (0.0)	1 (9.1)	0 (9.1)	0 (9.1)	0 (9.1)	0 (9.1)	3 (36.4)	2 (54.5)	1 (63.6)	0 (63.6)	4 (100.0)	2	>8
Micafungin			0 (0.0)	1 (9.1)	0 (9.1)	0 (9.1)	6 (63.6)	2 (81.8)	0 (81.8)	0 (81.8)	0 (81.8)	2 (100.0)	0.5	>8
Itraconazole					0 (0.0)	1 (9.1)	2 (27.3)	4 (63.6)	0 (63.6)	4 (100.0)			1	4
Voriconazole		0 (0.0)	1 (9.1)	0 (9.1)	1 (18.2)	2 (36.4)	3 (63.6)	4 (100.0)					0.5	1
Posaconazole				0 (0.0)	1 (9.1)	0 (9.1)	4 (45.5)	5 (90.9)	1 (100.0)				1	1
Amphotericin B					0 (0.0)	1 (9.1)	0 (9.1)	2 (27.3)	4 (63.6)			4 (100.0)	2	>2
Scedosporium aurantiacum (3)
Anidulafungin									0 (0.0)	1 (33.3)	1 (66.7)	1 (100.0)	8
Caspofungin											0 (0.0)	3 (100.0)	>8
Micafungin											0 (0.0)	3 (100.0)	>8
Itraconazole							0 (0.0)	1 (33.3)	0 (33.3)	0 (33.3)	0 (33.3)	2 (100.0)	>8
Voriconazole						0 (0.0)	1 (33.3)	2 (100.0)					1
Posaconazole							0 (0.0)	1 (33.3)	2 (100.0)				2
Amphotericin B								0 (0.0)	1 (33.3)			2 (100.0)	>2
Scedosporium (Lomentospora) prolificans (3)
Anidulafungin									0 (0.0)	2 (66.7)	0 (66.7)	1 (100.0)	4
Caspofungin										0 (0.0)	2 (66.7)	1 (100.0)	8
Micafungin										0 (0.0)	1 (33.3)	2 (100.0)	>8
Itraconazole											0 (0.0)	3 (100.0)	>8
Voriconazole											0 (0.0)	3 (100.0)	>8
Posaconazole											0 (0.0)	3 (100.0)	>8
Amphotericin B									0 (0.0)			3 (100.0)	>2
Exophiala dermatitidis (4)
Anidulafungin		0 (0.0)	1 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	1 (50.0)	2 (100.0)	8
Caspofungin		0 (0.0)	1 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	1 (50.0)	2 (100.0)	8
Micafungin	0 (0.0)	1 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	0 (25.0)	3 (100.0)	>8
Itraconazole					0 (0.0)	1 (25.0)	3 (100.0)						0.5
Voriconazole				0 (0.0)	3 (75.0)	1 (100.0)							0.12
Posaconazole					0 (0.0)	3 (75.0)	1 (100.0)						0.25
Amphotericin B						0 (0.0)	2 (50.0)	1 (75.0)	1 (100.0)				0.5
Geosmithia (Rasamsonia) argillacea (3)
Anidulafungin	2 (66.7)	1 (100.0)											< = 0.008
Caspofungin	0 (0.0)	3 (100.0)											0.015
Micafungin	2 (66.7)	1 (100.0)											< = 0.008
Itraconazole							0 (0.0)	1 (33.3)	0 (33.3)	0 (33.3)	0 (33.3)	2 (100.0)	>8
Voriconazole											0 (0.0)	3 (100.0)	>8
Posaconazole							0 (0.0)	1 (33.3)	2 (100.0)				2
Amphotericin B							0 (0.0)	2 (66.7)	1 (100.0)				1
Rhizopus microsporus group (9)
Anidulafungin		0 (0.0)	1 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	8 (100.0)	>8
Caspofungin		0 (0.0)	1 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	8 (100.0)	>8
Micafungin	0 (0.0)	1 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	8 (100.0)	>8
Itraconazole						0 (0.0)	2 (22.2)	5 (77.8)	1 (88.9)	0 (88.9)	0 (88.9)	1 (100.0)	1
Voriconazole						0 (0.0)	1 (11.1)	0 (11.1)	0 (11.1)	0 (11.1)	7 (88.9)	1 (100.0)	8
Posaconazole			0 (0.0)	1 (11.1)	0 (11.1)	1 (22.2)	3 (55.6)	2 (77.8)	2 (100.0)				0.5
Amphotericin B						0 (0.0)	1 (11.1)	6 (77.8)	2 (100.0)				1
Sarocladium kiliense (6)
Anidulafungin									0 (0.0)	2 (33.3)	2 (66.7)	2 (100.0)	8
Caspofungin				0 (0.0)	2 (33.3)	2 (66.7)	0 (66.7)	0 (66.7)	0 (66.7)	0 (66.7)	2 (100.0)		0.25
Micafungin				0 (0.0)	1 (16.7)	1 (33.3)	1 (50.0)	0 (50.0)	1 (66.7)	0 (66.7)	0 (66.7)	2 (100.0)	0.5
Itraconazole					0 (0.0)	1 (16.7)	0 (16.7)	0 (16.7)	0 (16.7)	0 (16.7)	0 (16.7)	5 (100.0)	>8
Voriconazole								0 (0.0)	6 (100.0)				2
Posaconazole					0 (0.0)	1 (16.7)	0 (16.7)	0 (16.7)	0 (16.7)	0 (16.7)	0 (16.7)	5 (100.0)	>8
Amphotericin B								0 (0.0)	1 (16.7)			5 (100.0)	>2

> represents the dilution greater than the highest dilution tested.