TABLE 4.

Summary of FKS alterations detected among Candida isolates displaying echinocandin MIC values above the ECV

Country or U.S. state	Organism	MIC (μg/ml) by CLSI methoda			1,3-β-d-Glucan synthase mutationsb
		Anidulafungin	Caspofungin	Micafungin	FKS1 HS1	FKS1 HS2	FKS2 HS1	FKS2 HS2
Italy	Candida albicans	0.12	0.12	0.06 (>ECV)	WT	WT	NT	NT
New York	Candida albicans	0.25	1 (R)	1 (R)	S645P	WT	NT	NT
Indiana	Candida albicans	0.5	1 (R)	1 (R)	S645P	WT	NT	NT
New York	Candida glabrata	0.25	0.5 (R)	0.03	WT	WT	P667T	NT
New York	Candida glabrata	0.5 (R)	0.25	0.25 (R)	WT	WT	S663P	WT
Slovenia	Candida glabrata	0.5 (R)	0.25	0.06 (>ECV)	WT	WT	WT	WT
Colorado	Candida glabrata	0.25	0.12	0.06 (>ECV)	WT	WT	WT	WT
Indiana	Candida glabrata	2 (R)	2 (R)	0.5 (R)	F625S	WT	F659Y	WT
Israel	Candida glabrata	2 (R)	2 (R)	2 (R)	WT	WT	F659S	WT
California	Candida glabrata	2 (R)	8 (R)	2 (R)	S629P	WT	WT	WT
California	Candida glabrata	0.25	0.5 (R)	0.25 (R)	WT	WT	F659S	WT
Australia	Candida glabrata	0.06	0.5 (R)	0.015	WT	WT	WT	WT
New York	Candida glabrata	2 (R)	2 (R)	2 (R)	WT	WT	S663P	WT
Canada	Candida glabrata	4 (R)	>8 (R)	4 (R)	S629P	WT	S663P	WT
Canada	Candida glabrata	4 (R)	>8 (R)	4 (R)	S629P	WT	S663P	WT
Georgia	Candida glabrata	2 (R)	2 (R)	0.5 (R)	F625S	WT	WT	WT
California	Candida glabrata	1 (R)	1 (R)	0.25 (R)	F625S	WT	WT	WT
Colorado	Candida glabrata	0.5 (R)	0.25	0.03	WT	WT	WT	WT
Virginia	Candida glabrata	0.12	0.06	0.12 (>ECV)	WT	WT	WT	WT
Turkey	Candida tropicalis	0.06	0.06	0.12 (>ECV)	WT	WT	NT	NT

^aR, resistant according to CLSI document MS7-S4 (13); >ECV, a concentration greater than the ECV according to CLSI document M59 (12).

^bNT, not tested; WT, wild type/no mutation detected.