TABLE 1.
Oxazolidinone-resistant mutant strains of M. tuberculosis H37Rv
| Strain | MIC on solid medium (μM) |
L3 mutation | 23S RNA mutation | |
|---|---|---|---|---|
| Linezolid | Sutezolid | |||
| H37Rv | 3.1 | 1.6 | WT | WT |
| LP-LZD-RM2 | 50 | 12.5 | WT | G2814T |
| LP-LZD-RM3 | 25 | 12.5 | WT | G2814T |
| LP-LZD-RM4 | 50 | 12.5 | WT | G2814T |
| LP-LZD-RM24 | 50 | 25 | WT | G2814T |
| LP-LZD-RM1 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM11 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM12 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM13 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM14 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM15 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM16 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM17 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM21 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM22 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM23 | 50 | 12.5 | C154R | WT |
| LP-LZD-RM25 | 50 | 12.5 | C154R | WT |
| HN878 WT | 1.6 | 0.4 | WT | WT |