TABLE 2.

Summary of plasma CAB PK parameters and treatment comparisons^a

Parameter	Geometric mean (95% CI)		GLSM ratio (90% CI)
	CABb (n = 15)	CAB + RIFc (n = 15)	CAB + RIF:CAB
AUC0–∞, μg · h/ml	146 (128–167)	59.7 (52.8–67.5)	0.41 (0.36–0.46)
Cmax, μg/ml	3.61 (3.28–3.96)	3.39 (3.05–3.76)	0.94 (0.87–1.02)
CL/F, liters/h	0.205 (0.180–0.234)	0.502 (0.444–0.568)	2.4 (2.2–2.8)
t1/2, h	38.5 (35.7–41.6)	16.4 (14.7–18.2)	0.43 (0.39–0.46)

^aAbbreviations: AUC_0–∞, area under the concentration-time curve from 0 h to infinity; CAB, cabotegravir; CI, confidence interval; CL/F, apparent clearance; C_max, maximum observed concentration; GLSM, geometric least-squares mean; PK, pharmacokinetics; RIF, rifampin; t_1/2, terminal elimination phase half-life.

^bFollowing a single dose of CAB 30 mg on day 1.

^cFollowing a single dose of CAB 30 mg on day 21 with once-daily administration of 600 mg RIF (days 8 to 28).