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. 2017 Sep 22;15:76. doi: 10.1186/s12958-017-0295-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Effect of altering AMPK on progesterone production by granulosa cells. a The AMPK activator, 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside [AICAR], inhibited progesterone production by human luteinized mural granulosal cells at all dosages tested. In b, the AMPK inhibitor, dorsomorphin [DM], did not affect basal progesterone production. Asterisks indicate a difference of (P < 0.05) from control value. All treatments were plated in triplicate for each experiment. N values for each treatment group are given in parenthesis above each column