Table 2.
Cause of early death (ED) and treatment related mortality (TRM) in the AML97 and AML02 trials. Early death (ED) is defined as death in induction prior to CR. Treatment related mortality (TRM) is defined as any death in first CR.
| AML97 (n=92) | AML02 (n=216) | |||||
|---|---|---|---|---|---|---|
| Cause of death | ED | TRM | ED | TRM | ||
| Chemotherapy alone | Allogeneic HCT (n=39) | Chemotherapy alone | Allogneic HCT (n=60) | |||
| Infection | 2 | 4 | 10 | 0 | 7 | 4 |
| Bleeding | 0 | 0 | 0 | 1 | 0 | 1 |
| Cardiovascular failure | 0 | 0 | 1 | 0 | 1 | 0 |
| Graft versus host | 0 | 0 | 0 | 0 | 0 | 1 |
| Other | 0 | 0 | 0 | 0 | 0 | 3 |
| Total - N (5 year CI) | 2 | 4 (6.5%) | 11 (35.5%) | 1 | 8 (4.1%) | 9 (15.1%) |