Table 3.
Association Between Vessel Density and Demographic and Ocular Variables: Multivariable Analysis*
| Vessel Density (%) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Whole | Superior | Inferior | ParaFovea | |||||
| Variables | Coefficients (95%CI) | P Value | Coefficients (95%CI) | P Value | Coefficients (95%CI) | P Value | Coefficients (95%CI) | P Value |
| Age (per y.) | −0.08 (−0.17, 0.01) | 0.086 | −0.13 (−0.27, 0.02) | 0.084 | −0.09 (−0.25, 0.06) | 0.230 | −0.08 (−0.18, 0.01) | 0.085 |
| Glaucoma (reference: Glaucoma) | ||||||||
| Healthy | 1.02 (−1.18, 3.21) | 0.364 | 0.85 (−2.44, 4.14) | 0.611 | −0.16 (−3.28, 2.96) | 0.919 | 0.42 (−2.01, 2.84) | 0.738 |
| Glaucoma Suspect | 1.07 (−1.09, 3.24) | 0.331 | 1.56 (−0.95, 4.08) | 0.222 | 1.46 (−1.07, 3.99) | 0.258 | 0.73 (−1.64, 3.10) | 0.548 |
| Time (per y.) | −1.99 (−3.18, −0.81) | 0.001 | −1.64 (−3, −0.27) | 0.019 | −2.86 (−4.17, −1.54) | <0.001 | −2.99 (−4.67, −1.33) | 0.001 |
| Diastolic Blood Pressure (per mmHg) | 0.00 (−0.14, 0.15) | 0.959 | −0.01 (−0.19, 0.16) | 0.882 | 0.02 (−0.18, 0.21) | 0.871 | 0.02 (−0.12, 0.16) | 0.814 |
| MOPP (per mmHg) | 0.07 (−0.06, 0.20) | 0.315 | 0.07 (−0.08, 0.23) | 0.355 | 0.04 (−0.14, 0.22) | 0.687 | 0.09 (−0.04, 0.21) | 0.170 |
| SSI (per unit) | 0.25 (0.16, 0.34) | <0.001 | 0.22 (0.12, 0.32) | <0.001 | 0.28 (0.17, 0.40) | <0.001 | 0.28 (0.18, 0.38) | <0.001 |
| Time x glaucoma (reference: Glaucoma)(per y.) | ||||||||
| Healthy | 2.13 (0.53, 3.74) | 0.009 | 2.23 (0.19, 4.28) | 0.033 | 3.77 (1.92, 5.62) | <0.001 | 3.33 (1.24, 5.41) | 0.002 |
| Glaucoma Suspect | 2.30 (0.99, 3.60) | 0.001 | 2.24 (0.71, 3.76) | 0.004 | 2.86 (1.13, 4.60) | 0.001 | 3.11 (1.19, 5.02) | 0.001 |
| Para-Temporal | Para-Superior | Para-Nasal | Para-Inferior | |||||
|---|---|---|---|---|---|---|---|---|
| Variables | Coefficients (95%CI) | P Value | Coefficients (95%CI) | P Value | Coefficients (95%CI) | P Value | Coefficients (95%CI) | P Value |
| Age (per y.) | −0.07 (−0.17, 0.03) | 0.191 | −0.11 (−0.2, −0.01) | 0.024 | −0.09 (−0.19, 0.01) | 0.071 | −0.06 (−0.17, 0.05) | 0.286 |
| Glaucoma (reference: Glaucoma) | ||||||||
| Healthy | 0.58 (−1.99, 3.16) | 0.657 | 1.62 (−0.92, 4.16) | 0.212 | −0.37 (−2.84, 2.1) | 0.770 | 0.74 (−1.8, 3.27) | 0.568 |
| Glaucoma Suspect | 1.21 (−1.12, 3.54) | 0.309 | 1.27 (−1.28, 3.82) | 0.329 | −0.02 (−2.57, 2.53) | 0.988 | 1.72 (−0.85, 4.28) | 0.189 |
| Time (per y.) | −1.62 (−3.12, −0.13) | 0.033 | −1.49 (−3.29, 0.32) | 0.106 | −3.02 (−4.62, −1.43) | <0.001 | −2.58 (−4.05, −1.10) | 0.001 |
| Diastolic Blood Pressure (per mmHg) | −0.03 (−0.18, 0.12) | 0.715 | 0.05 (−0.09, 0.20) | 0.448 | 0.01 (−0.14, 0.16) | 0.945 | 0.04 (−0.13, 0.21) | 0.646 |
| MOPP (per mmHg) | 0.11 (−0.04, 0.27) | 0.154 | 0.03 (−0.09, 0.15) | 0.627 | 0.08 (−0.04, 0.20) | 0.199 | 0.08 (−0.08, 0.25) | 0.330 |
| SSI (per unit) | 0.25 (0.14, 0.35) | <0.001 | 0.25 (0.15, 0.35) | <0.001 | 0.29 (0.17, 0.40) | <0.001 | 0.3 (0.19, 0.42) | <0.001 |
| Time x glaucoma (reference: Glaucoma)(per y.) | ||||||||
| Healthy | 2.08 (0.09, 4.07) | 0.040 | 1.61 (−0.61, 3.83) | 0.155 | 2.99 (0.84, 5.14) | 0.006 | 3.25 (1.17, 5.33) | 0.002 |
| Glaucoma Suspect | 1.83 (0.11, 3.56) | 0.037 | 1.54 (−0.58, 3.67) | 0.154 | 3.06 (1.07, 5.05) | 0.003 | 2.4 (0.44, 4.36) | 0.016 |
Abbreviations: CI, confidence interval; y, years; MOPP, mean ocular perfusion pressure; SSI, signal strength index