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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Kidney Int. 2017 May 26;92(4):909–921. doi: 10.1016/j.kint.2017.03.027

Figure 10.

Figure 10

Potential crosstalk between JAK-STAT and Ang II signaling pathways in response to JAK1/2 inhibition in glomeruli from JAK2 diabetic mice. These interactions were based on known interactions (Jun) and analysis of potentially cooperating transcription factor binding sites in genes that were responsive to inhibitor treatment that were identified by analysis of Multiple Organized Regulatory Element cassettes (MORE) cassettes (see Methods). Black circles: known JAK2 inducers; grey ovals: angiotensin II responsive receptors; white circles: transcription factors; white rectangles: transcription factor binding sites in MORE-cassettes for the respective transcription factors.