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. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Kidney Int. 2017 May 26;92(4):909–921. doi: 10.1016/j.kint.2017.03.027

Effect of treatment with a JAK1/JAK2 inhibitor on diabetic glomerular changes in JAK2 diabetic mice. Oral treatment with the JAK1/JAK2 inhibitor for the last 2 weeks of the experiment resulted in a significant decrease in albuminuria (A), mesangial expansion and glomerular volume (B) compared to treatment with vehicle alone as shown in PAS-stained glomerular sections (top) and expressed as PAS-positive percent mesangial area and as glomerular volume (bottom). (C) Glomerular levels of phosphorylated and total STAT3 and their ratios were determined by immunoblotting with specific antibodies. Animals treated with the JAK1/JAK2 inhibitor showed a significant reduction in relative phosphorylation of STAT3. Number of animals in each group is indicated in parentheses above each bar in the graphs. *p < 0.05, **p < 0.01. Scale bars are 50 μm in length.

Effect of treatment with a JAK1/JAK2 inhibitor on diabetic glomerular changes in JAK2 diabetic mice. Oral treatment with the JAK1/JAK2 inhibitor for the last 2 weeks of the experiment resulted in a significant decrease in albuminuria (A), mesangial expansion and glomerular volume (B) compared to treatment with vehicle alone as shown in PAS-stained glomerular sections (top) and expressed as PAS-positive percent mesangial area and as glomerular volume (bottom). (C) Glomerular levels of phosphorylated and total STAT3 and their ratios were determined by immunoblotting with specific antibodies. Animals treated with the JAK1/JAK2 inhibitor showed a significant reduction in relative phosphorylation of STAT3. Number of animals in each group is indicated in parentheses above each bar in the graphs. *p < 0.05, **p < 0.01. Scale bars are 50 μm in length.