Table 1.
Physiological data.
| Control | Control diabetic | JAK2 | JAK2 diabetic | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| 0 week | 4 week | 0 week | 4week | 0 week | 4week | 0 week | 4week | |
| BW (g) | 24.8 ± 0.5 (9) | 25.9 ± 0.6 (9) | 22.0 ± 0.5 (8) | 22.6 ± 0.5 (8)* | 25.5 ± 0.8 (9) | 25.5 ± 0.2 (9) | 22.0 ± 0.2 (8) | 21.8 ± 0.6 (8)≠ |
| FBG (mg/dL) | 143.9 ± 4.0 (9) | 147.2 ± 6.3 (9) | 607.4 ±27.3 (8) | 616.1 ±24.9 (8)* | 144.1 ± 5.1 (9) | 120.9 ± 9.9 (9) | 583.3 ±12.7 (8) | 556.4 ±22.6 (8)≠ |
| SBP (mmHg) | 93.0 ± 4.6 (5) | 143.9 ± 4.6 (9) | 90.02 ± 2.9 (5) | 144.0 ± 1.5 (8) | 94.4 ± 3.23 (5) | 143.1 ± 9.4 (9) | 93.6 ± 2.6 (5) | 139.5 ± 5.7 (8) |
| GHb (%) | 4.6 ± 0.1 (9) | 11.2 ± 0.3 (8)*≠ | 4.7 ± 0.1 (9) | 10.5 ± 0.2 (8)*≠ | ||||
| KW (g) | 0.21 ± 0.01 (9) | 0.23 ± 0.01 (8)*≠ | 0.20 ± 0.01 (9) | 0.27 ± 0.02 (8)*≠ | ||||
| KW/BW (mg/g) | 8.0 ± 0.5 (9) | 10.4 ± 0.4 (8)*≠ | 8.0 ± 0.2 (9) | 12.3 ± 0.6 (8)*≠ # | ||||
| HDL (mg/dL) | 69.0 ± 5.9 (9) | 104.6 ± 8.2 (8)*≠ | 74.0 ± 2.6 (9) | 121.9 ± 9.5 (8)*≠ | ||||
| Tot. Chol. (mg/dL) | 108.8 ± 1.7 (9) | 176.5 ±17.6(8)*≠ | 112.4 ± 2.7 (9) | 198.6 ± 25.7 (8)*≠ | ||||
| Pl. Creat. (mg/dL) | 0.090 ± 0.007 (5) | 0.138 ± 0.009 (5)*≠ | 0.076 ± 0.010 (5) | 0.123 ± 0.005 (7)*≠ | ||||
Abbreviations: BW – body weight, FBG – fasting blood glucose, GHb – glycated hemoglobin, SBP – systolic blood pressure, KW – left kidney weight, KW/BW – left kidney weight/body weight, Tot. Chol. – total cholesterol, Pl. Creat. – plasma creatinine.
Data are presented as means ± SEM with total number of animals in parentheses.
*
vs. Control,
≠
vs. JAK2,
#
vs. Control diabetic, p< 0.05.
All 4 wk SBP values were significantly different (p<0.05) than the respective 0 wk values. There were no significant differences between SBP at 0 and 4 wks in any of the groups.