Table 2.

Glomerular morphometry

Experiment 1
	Control	Control diabetic	JAK2	JAK2 diabetic
Glom Vol (x 103 μm3)	183.6 ±19.9	291.2 ± 12.6 *≠	194.8 ± 24.9	351.5 ± 21.8 *≠
PON	70.2 ± 4.2	73.0 ± 3.4	64.0 ± 4.6	65.4 ± 7.2
P/GVt (x 10−4/μm3)	3.90 ± 0.26	2.52 ± 0.15 *	3.44 ± 0.34	1.88 ± 0.21*≠

Experiment 2
	JAK2 diabetic + vehicle	JAK2 diabetic + JAK1/2 inhibitor
Glom Vol (x 103 μm3)	298.8 ± 32.4	264.2 ± 27.4*
PON	67.2 ± 3.4	71.2 ± 3.5
P/GVt (x 10−4/μm3)	2.32 ± 0.21	2.82 ± 0.29

Abbreviations: Glom Vol – glomerular volume, P/GVt – Podocyte number per glomerular volume, PON - podocyte number/glomerulus.

Data are presented as means ± SEM, n = 5 (Experiment 1) or 6 (Experiment 2) per group.

^*p< 0.05, vs. Control,

^≠vs. JAK2,

^#vs. Control DM.