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. Author manuscript; available in PMC: 2018 Aug 12.
Published in final edited form as: Curr Opin Virol. 2017 Aug 12;25:90–96. doi: 10.1016/j.coviro.2017.07.028

Figure 1.

Figure 1

Characteristics of human immune system mouse models used in Ebola virus infection studies. All strains are derived from a NOD-scid/IL2Rγ−/− (NSG) background and are injected intravascularly with either human peripheral blood lymphocytes (PBL) or hematopoietic stem cells (HSC). Strains vary in human transgene expression, and in presence or absence of co-engrafted, donor-matched human liver and thymic tissue. Human cell engraftment and responses are indicated as (−) absent, (+) present, or (+/−) may only be present in low numbers and may not be functional. CTL: cytotoxic T lymphocyte; GVHD: graft versus host disease; NK: natural killer cells; pDC: plasmacytoid dendritic cells; Treg: regulatory T cells.