Table 4.

Candidate risk factors for febrile neutropenia in cycle 1 (data re-analysis by multivariate analysis)

	Parameter estimate (standard error)	Odds ratio [95% CI]	p value
Age (years) (<65, ≥65)	0.72 (0.41)	2.06 [0.928–4.549]	0.0756
Sex (male, female)	0.50 (0.36)	1.65 [0.821–3.318]	0.1599
Disease stage (I–II, III–IV)	0.60 (0.38)	1.82 [0.864–3.835]	0.1154
Albumin (g/L) (≥35, <35)	0.66 (0.41)	1.93 [0.867–4.275]	0.1076
Relative dose intensity (≥85, <85%)	1.02 (0.38)	2.78 [1.332–5.805]	0.0064
Prophylaxis with G-CSF (no, yes)	−1.40 (0.38)	0.25 [0.117–0.524]	0.0003
Estimated FN incidence in cycle 1 without prophylaxis with G-CSF: simulation analysis
%		95% CI
16.2		10.9–22.2

CI confidence interval, G-CSF granulocyte colony-stimulating factor, N number of patients analyzed, FN febrile neutropenia